Inhibition of influenza A virus infection by ginsenosides.
Identifieur interne : 000A89 ( Main/Exploration ); précédent : 000A88; suivant : 000A90Inhibition of influenza A virus infection by ginsenosides.
Auteurs : Wei Dong [République populaire de Chine] ; Amber Farooqui [République populaire de Chine] ; Alberto J. Leon [République populaire de Chine] ; David J. Kelvin [République populaire de Chine]Source :
- PloS one [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Cellules CHO, Cellules rénales canines Madin-Darby, Chiens, Cricetinae, Cricetulus, Femelle, Ginsénosides (pharmacologie), Ginsénosides (usage thérapeutique), Glycoprotéine hémagglutinine du virus influenza (métabolisme), Infections à Orthomyxoviridae (traitement médicamenteux), Liaison aux protéines, Souris, Souris de lignée BALB C, Virus de la grippe A (pathogénicité).
- MESH :
- métabolisme : Glycoprotéine hémagglutinine du virus influenza.
- pathogénicité : Virus de la grippe A.
- pharmacologie : Antiviraux, Ginsénosides.
- traitement médicamenteux : Infections à Orthomyxoviridae.
- usage thérapeutique : Antiviraux, Ginsénosides.
- Animaux, Cellules CHO, Cellules rénales canines Madin-Darby, Chiens, Cricetinae, Cricetulus, Femelle, Liaison aux protéines, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), CHO Cells, Cricetinae, Cricetulus, Dogs, Female, Ginsenosides (pharmacology), Ginsenosides (therapeutic use), Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Influenza A virus (pathogenicity), Madin Darby Canine Kidney Cells, Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (drug therapy), Protein Binding.
- MESH :
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , pharmacology : Antiviral Agents, Ginsenosides.
- chemical , therapeutic use : Antiviral Agents, Ginsenosides.
- drug therapy : Orthomyxoviridae Infections.
- pathogenicity : Influenza A virus.
- Animals, CHO Cells, Cricetinae, Cricetulus, Dogs, Female, Madin Darby Canine Kidney Cells, Mice, Mice, Inbred BALB C, Protein Binding.
Abstract
Influenza viruses cause mild to severe respiratory infections in humans. Due to efficient means of transmission, the viruses infect human population on a large scale. Apart from vaccines, antiviral drugs are used to control infection; neuraminidase inhibitors are thought to be the first choice of treatment, particularly for severe cases. Rapidly evolving and emerging influenza viruses with increased frequency of viral resistance to these drugs stress the need to explore novel antiviral compounds. In this study, we investigated antiviral activity of ginseng extract and ginsenosides, the ginseng-derived triterpene and saponin compounds, against 2009 pandemic H1N1 virus in vitro and in vivo. Our data showed that treatment of mice with ginsenosides protected the animals from lethal 2009 pandemic H1N1 infection and lowered viral titers in animal lungs. Mechanistic studies revealed that ginsenosides interact with viral hemagglutinin protein and prevent the attachment of virus with α 2-3' sialic acid receptors present on host cell surfaces. The interference in the viral attachment process subsequently minimizes viral entry into the cells and decreases the severity of the viral infection. We also describe that sugar moieties present in ginsenosides are indispensible for their attachment with viral HA protein. On the basis of our observations, we can say that ginsenosides are promising candidates for the development of antiviral drugs for influenza viruses.
DOI: 10.1371/journal.pone.0171936
PubMed: 28187149
Affiliations:
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Le document en format XML
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Leon</name><affiliation wicri:level="1"><nlm:affiliation>Division of Immunology, International Institute of Infection and Immunity, University Health Network & Shantou University Medical College, Shantou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Immunology, International Institute of Infection and Immunity, University Health Network & Shantou University Medical College, Shantou</wicri:regionArea><wicri:noRegion>Shantou</wicri:noRegion></affiliation></author><author><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J" last="Kelvin">David J. Kelvin</name><affiliation wicri:level="1"><nlm:affiliation>Division of Immunology, International Institute of Infection and Immunity, University Health Network & Shantou University Medical College, Shantou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Immunology, International Institute of Infection and Immunity, University Health Network & Shantou University Medical College, Shantou</wicri:regionArea><wicri:noRegion>Shantou</wicri:noRegion></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>CHO Cells</term><term>Cricetinae</term><term>Cricetulus</term><term>Dogs</term><term>Female</term><term>Ginsenosides (pharmacology)</term><term>Ginsenosides (therapeutic use)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (metabolism)</term><term>Influenza A virus (pathogenicity)</term><term>Madin Darby Canine Kidney Cells</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (drug therapy)</term><term>Protein Binding</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Cellules CHO</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Cricetinae</term><term>Cricetulus</term><term>Femelle</term><term>Ginsénosides (pharmacologie)</term><term>Ginsénosides (usage thérapeutique)</term><term>Glycoprotéine hémagglutinine du virus influenza (métabolisme)</term><term>Infections à Orthomyxoviridae (traitement médicamenteux)</term><term>Liaison aux protéines</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Ginsenosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Ginsenosides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Ginsénosides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Ginsénosides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>CHO Cells</term><term>Cricetinae</term><term>Cricetulus</term><term>Dogs</term><term>Female</term><term>Madin Darby Canine Kidney Cells</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Protein Binding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules CHO</term><term>Cellules rénales canines Madin-Darby</term><term>Chiens</term><term>Cricetinae</term><term>Cricetulus</term><term>Femelle</term><term>Liaison aux protéines</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza viruses cause mild to severe respiratory infections in humans. Due to efficient means of transmission, the viruses infect human population on a large scale. Apart from vaccines, antiviral drugs are used to control infection; neuraminidase inhibitors are thought to be the first choice of treatment, particularly for severe cases. Rapidly evolving and emerging influenza viruses with increased frequency of viral resistance to these drugs stress the need to explore novel antiviral compounds. In this study, we investigated antiviral activity of ginseng extract and ginsenosides, the ginseng-derived triterpene and saponin compounds, against 2009 pandemic H1N1 virus in vitro and in vivo. Our data showed that treatment of mice with ginsenosides protected the animals from lethal 2009 pandemic H1N1 infection and lowered viral titers in animal lungs. Mechanistic studies revealed that ginsenosides interact with viral hemagglutinin protein and prevent the attachment of virus with α 2-3' sialic acid receptors present on host cell surfaces. The interference in the viral attachment process subsequently minimizes viral entry into the cells and decreases the severity of the viral infection. We also describe that sugar moieties present in ginsenosides are indispensible for their attachment with viral HA protein. On the basis of our observations, we can say that ginsenosides are promising candidates for the development of antiviral drugs for influenza viruses.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Dong, Wei" sort="Dong, Wei" uniqKey="Dong W" first="Wei" last="Dong">Wei Dong</name></noRegion><name sortKey="Farooqui, Amber" sort="Farooqui, Amber" uniqKey="Farooqui A" first="Amber" last="Farooqui">Amber Farooqui</name><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J" last="Kelvin">David J. Kelvin</name><name sortKey="Leon, Alberto J" sort="Leon, Alberto J" uniqKey="Leon A" first="Alberto J" last="Leon">Alberto J. Leon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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